Pittsburgh quarterback Eli Holstein will not play against No. 20 Clemson, sources told ESPN, with redshirt junior Nate Yarnell set to get the start.

Pitt will turn to backup quarterback Nate Yarnell when they host No. 20 Clemson on Saturday, as starter Eli Holstein has been ruled out following head injuries in the past two games. According to ESPN’s Pete Thamel,

After two head injuries in the past three games, Pitt quarterback Eli Holstein is not expected to start Saturday when the Panthers meet Clemson at Acrisure Stadium. Nate Yarnell is expected to make his fourth career start — first this season — in a make-or-break game for Pitt (7-2,

Holstein left Pitt's game against Virginia last week with a head injury​ and is questionable for the ACC matchup against the No. 17 ranked Tigers.

It will be a game-time decision for Eli Holstein this weekend. Pat Narduzzi announced Thursday at his weekly presser that Holstein has not been cleared by the Pitt medical staff yet, and his status is a game-time decision. Narduzzi said that Pitt has confidence in both Holstein and backup Nate Yarnell, but obviously, Holstein will play if healthy.

Pat Narduzzi walked inside the big conference room adjacent to his office Thursday afternoon and correctly read the minds of the assembled reporters. “Probably the big question is how is Eli doing, right?

After leaving each of the past two games with a head injury, the status for Pitt starting quarterback Eli Holstein is up in the air for Saturday’s matchup with No. 20 Clemson. On Thursday,

There's no hiding it. After starting the season 7-0 and getting off to its best start in over 40 years, Pitt has played its worst football over the last two weeks of the season, both of which resulted in disappointing losses.

Injured against Virginia, Pitt head coach Pat Narduzzi said Eli Holstein has not been cleared to play, at least yet, so quarterback is a game-time decision

The Pittsburgh Panthers got off to their first 7-0 start since 1982, and perhaps the biggest reason for a flawless opening two months was the presence of redshirt freshman quarterback Eli Holstein. The Alabama transfer burst onto the scene and immediately looked the part of a former 4-star recruit finding his form as a starter.

Pitt Panthers redshirt freshman Eli Holstein departed the last game vs. Virginia with an injury, putting his availability into question ahead of their Week 12 matchup vs. Clemson. Holstein would rush five yards and slide down on a drive in the third quarter,